NOTE 22B: These data come from Patterson et al. (2006); see commentary by Barton (2006).
NOTE 22C: This model of speciation is developed by Orr (1995) and in subsequent papers.
NOTE 22D: This formula is given by Lande (1979).
NOTE 22E: This analysis of fixation probability was outlined by Wright (1941) and laid out in more detail by Lande (1979), who introduced the idea of spread by extinction and recolonization.
NOTE 22F: Ignoring linkage disequilibrium is an accurate approximation when selection is weak relative to recombination. Although there is very strong selection against APBP, these genotypes remain rare, and so this is a good approximation.